Hamminger P, Marchetti L, Preglej T, Platzer R, Zhu C, Kamnev A, Rica R, Stolz V, Sandner L, Alteneder M, Kaba E, Waltenberger D, Huppa JB, Trauner M, Bock C, Lyck R, Bauer J, Dupré L, Seiser C, Boucheron N, Engelhardt B, Ellmeier W. (2021). Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. J Autoimmun. 119:102610. doi: 10.1016/j.jaut.2021.102610 PubMed link
CD4+ T cell trafficking is a fundamental property of adaptive immunity. In this study, we uncover a novel role for histone deacetylase 1 (HDAC1) in controlling effector CD4+ T cell migration, thereby providing mechanistic insight into why a T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis (EAE).
Krausgruber T, Fortelny N, Fife-Gernedl V, Senekowitsch M, Schuster LC, Lercher A, Nemc A, Schmidl C, Rendeiro AF, Bergthaler A, Bock C. (2020). Structural cells are key regulators of organ-specific immune responses. Nature, 583(7815):296-302. doi: 10.1038/s41586-020-2424-4. PubMed link
Immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence.
Ellmeier W and Seiser C. (2018). Histone deacetylase function in CD4+ T cells. Nature Reviews Immunology, 18, 617-634. PubMed link
Histone deacetylases (HDACs) and histone acetyltransferases mediate reversible acetylation of histones and many other non-histone proteins to regulate gene expression and protein function. Here, we describe the myriad activities of HDACs in CD4+ T cells and the potential use of HDAC inhibitors as therapeutics for immune-mediated diseases.
Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih HY, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M. (2020). Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J Autoimmun. 108:102379. PubMed link
Here were report that HDAC1 function in T cells is important for the development of rheumatoid arthritis. These data suggest that selective inhibition of HDAC1 might be a novel treatment strategy for RA.
SFB members also contributed to research projects in the hosting laboratories unrelated to the topic of the SFB. These publications (a selection) are listed in italics.
2022
Hollenstein DM, Veis J, Romanov N, Gérecová G, Ogris E, Hartl M, Ammerer G, Reiter W (2022). PP2ARts1 antagonizes Rck2-mediated hyperosmotic stress signaling in yeast. Microbiological Research. 260: 127031. doi: 10.1016/j.micres.2022.127031 PubMed link
Jenull S, R Shivarathri, I Tsymala, P Penninger, Phan-Canh, F Nogueira, M Chauhan, A Singh, A Petryshyn, A Stoiber, A Chowdhary, N Chauhan & K Kuchler (2022). Transcriptomics and phenotyping define genetic signatures associated with echinocandin resistance in C. auris. mBio In press
Preglej T and Ellmeier W., (2022). CD4+ Cytotoxic T cells - Phenotype, Function and Transcriptional Networks Controlling Their Differentiation Pathways. Immunol Lett. 2022 Jul;247:27-42. doi: 10.1016/j.imlet.2022.05.001. PubMed link
Shivarathri R, M Chauhan, R Mazumdar, T Phan-CanhTrinh, W Reiter, M Hartl, K Kuchler, & N Chauhan (2022) A Proteomic Approach for the Quantification of Post-translational Protein Lysine Acetylation in Candida albicans. Methods Mol Biol, In press
bioRxiv (not peer-reviewed)
Madern M, Reiter W, Stanek F, Hartl N, Mechtler K, Hartl M. (2022). A causal model of ion interference enables assessment and correction of ratio compression in multiplex proteomics. bioRxiv. doi: 10.1101/2022.06.24.497446 https://www.biorxiv.org/content/10.1101/2022.06.24.497446v1
Varnavides G, Madern M, Anrather D, Hartl N, Reiter W, Hartl M. (2022). In search of the universal method: a comparative survey of bottom-up proteomics sample preparation methods. bioRxiv. under revision,doi: 10.1101/2022.05.04.490597 https://www.biorxiv.org/content/10.1101/2022.05.04.490597v1
Didusch S, Madern M, Hartl M, Baccarini M. (2022). amica: an interactive and user-friendly web-platform for the analysis of proteomics data. bioRxiv.
doi: 10.1101/2021.11.23.466958
https://www.biorxiv.org/content/10.1101/2021.11.23.466958v2
2021
Datlinger P*, Rendeiro AF*, Boenke T, Senekowitsch M, Krausgruber T, Barreca D, Bock C: Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing (2021). Nature Methods,18(6):635-642.
doi: 10.1038/s41592-021-01153-z. PubMed link
Hamminger P, Marchetti L, Preglej T, Platzer R, Zhu C, Kamnev A, Rica R, Stolz V, Sandner L, Alteneder M, Kaba E, Waltenberger D, Huppa JB, Trauner M, Bock C, Lyck R, Bauer J, Dupré L, Seiser C, Boucheron N, Engelhardt B, Ellmeier W. (2021). Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. J Autoimmun. 119:102610. doi: 10.1016/j.jaut.2021.102610 PubMed link
Hollenstein DM, Gérecová G, Romanov N, Ferrari J, Veis J, Janschitz M, Beyer R, Schüller C, Ogris E, Hartl M, Ammerer G, Reiter W (2021). A phosphatase‐centric mechanism drives stress signaling response. EMBO Reports. 22(11): e52476. doi: 10.15252/embr.202152476 PubMed link
Jenull S, Tscherner, M, Mair T, Stoiber A, Penninger P, Riedelberger M, Mair T, Shivarathri R, Chauhan N, Leibundgut-Landtmann S, Zacchi L, et al. & K Kuchler (2021). The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence. Cell Reports 2021 Jul 20;36(3):109406. doi.org/10.1016/j.celrep.2021.109406 PubMed link
Penninger, P, M Riedelberger, I Tsymala, H Arzani, S Jenull & K Kuchler (2021). Quantification of Zinc intoxication of C. glabrata after phagocytosis by macrophages. STAR Protocols:100352 https://doi.org/10.1016/j.xpro.2021.100352 PubMed link
Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M. (2021). 4-NorUrsodeoxycholic acid reshapes immunometabolism in CD8 + T-cells and alleviates hepatic inflammation. 75(5):1164-1176. doi: 10.1016/j.jhep.2021.06.036. PubMed link
2020
Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih HY, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M. (2020). Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J Autoimmun. 108:102379. PubMed link
Hamminger P, Rica R, Ellmeier W. (2020) Histone deacetylases as targets in autoimmune and autoinflammatory diseases. Adv Immunol. 147:1-59. doi: 10.1016/bs.ai.2020.06.001 PubMed link
Jenull S, Tscherner M, Mair T & K Kuchler (2020). ATAC-seq identifies chromatin landscapes linked to the regulation of oxidative stress in the fungal pathogen C. albicans. J Fungi, 6: 182; doi.org/10.3390/jof6030182 PubMed link
Krausgruber T, Fortelny N, Fife-Gernedl V, Senekowitsch M, Schuster LC, Lercher A, Nemc A, Schmidl C, Rendeiro AF, Bergthaler A, Bock C. (2020). Structural cells are key regulators of organ-specific immune responses. Nature, 583(7815):296-302. doi: 10.1038/s41586-020-2424-4. PubMed link
Pinheiro DF, Szenes-Nagy AB, Maurano MM, Lietzenmayer M, Klicznik MM, Holly R, Kirchmeier D, Kitzmueller S, Achatz-Straussberger G, Rosenblum MD, Thalhamer J, Abbas AK, Gratz IK (* 1st authors contributed equally). Cutting Edge: Tissue Antigen Expression Levels Fine-Tune T Cell Differentiation Decisions In Vivo. J Immunol October 9, 2020, ji1901094; doi: https://doi.org/10.4049/jimmunol.1901094 PubMed link
Preglej T, Hamminger P, Luu M, Bulat T, Andersen L, Göschl L, Stolz V, Rica R, Sandner L, Waltenberger D, Tschismarov R, Faux T, Boenke T, Laiho A, Elo LL, Sakaguchi S, Steiner G, Decker T, Bohle B, Visekruna A, Bock C, Strobl B, Seiser C, Boucheron N, Ellmeier W. (2020). Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation. JCI Insight, 5(4). pii: 133393. PubMed link
Riedelberger, M., P. Penninger, M. Tscherner, M. Seifert, S. Jenull, C. Brunnhofer, B. Scheidl, C. Bourgeois, A. Petryshyn, W. Glaser, A. Limbeck, G. Weiss, & K. Kuchler (2020). Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection. Cell Host Microbe. 27(3):454-466.e8.
doi.org/10.1016/j.chom.2020.01.023
PubMed link
Important publications on SFB topics before the establishment of the SFB in 2019
Ellmeier, W. and Seiser, C. (2018). Histone deacetylase function in CD4+ T cells. Nature Reviews Immunology, 18, 617-634. PubMed link
Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W. (2018). A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. Journal of Autoimmunity, 86:51-61. doi: 10.1016/j.jaut.2017.09.008. PubMed link
Boucheron, N, Tschismarov, R, Göschl, L, Moser, Mirjam, Lagger, S, Sakaguchi, S, Winter, Lenz, F, Vitko, D., Breitwieser, FP, Haust, L, Hassan, H, Bennett, KL, Colinge, J, Schreiner, W, Matthias, P, Egawa, T, Taniuchi, I, Matthias, P, Seiser, C and Ellmeier, W. (2014). CD4 T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nature Immunology, 15(5):439-48. PubMed link
Tschismarov R, Firner S, Gil-Cruz C, Göschl L, Boucheron N, Steiner G, Matthias P, Seiser C, Ludewig B, Ellmeier W. (2014). HDAC1 controls CD8+ T cell homeostasis and antiviral response. PLoS One. 2014 Oct 21;9(10):e110576. doi: 10.1371/journal.pone.0110576. PubMed link
Grausenburger, R, Bilic, I., Boucheron, N., Zupkovitz, G., El-Housseiny, L., Tschismarov, R., Zhang, Y., Rembold, M., Gaisberger, M., Hartl, A., Epstein, M.M., Matthias, P., Seiser, C., Ellmeier, W. (2010). Conditional deletion of HDAC1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. Journal of Immunology, 185(6): 3489-97. PubMed link